The intensity of the adverse reactions depends on dosage and route of administration. An initial dose titration will often reduce the adverse reactions. Adverse reactions which have been recorded, e.g. tremor, headache, nausea, tonic muscle cramps, tachycardia and palpitations, are all characteristic of sympathomimetic amines. The majority of these effects have reversed spontaneously within the first 1-2 weeks of treatment.
As for all β
2-agonists, cardiac arrhythmias, e.g. atrial fibrillation, supraventricular tachycardia and extrasystoles have been rarely reported.
Urticaria and exanthema may occur.
Sleep disturbances and behavioural disturbances, such as agitation, hyperactivity and restlessness, have been observed.