Bronchofen Drug Interactions

The use of phenylephrine together with other sympathomimetic agents (like epinephrine) maybe hazardous and increases the risk for toxicity. These may result from the pharmacologic activities of alpha and beta-adrenergic receptor stimulation.
Sympathomimetic agents should be used with caution in patients who are taking antihypertensive medications specially those which directly involve the sympathetic nervous system.
Patients taking MAOI's/anti-depressants (like Sertraline, Amitriptyline, Imipramine) may experience sudden, severe blood pressure elevation that can potentially lead to stoke. MAOIs increases the amount of noradrenaline which are stored in the nerve endings that may interact with other sympathomimetic agents.
Adrenergic receptor blockers (like propranolol, phenothiazine, phentolamine,) may decrease the effect of phenylephrine.
Antihistamines in general may increase the sedating effects of CNS depressants like antipsychotics, anxiolytic sedatives, opioid analgesics, hypnotics, barbiturates and alcohol.