Bronchofen Mechanism of Action

Pharmacology: Pharmacodynamics and Pharmacokinetics: Bronchofen combines two widely used agents, phenylephrine HCl and chlorpheniramine maleate which provide relief of symptoms such as nasal congestion, watery eyes, sneezing, itchiness and runny nose that accompany common cold, sinusitis and allergic rhinitis.
Phenylephrine, a decongestant, relieves nasal congestion associated with common cold, hay fever/allergic rhinitis, sinusitis and other respiratory diseases.
Chlorpheniramine maleate, an antihistamine, relieves itchiness and other clinical expressions of allergy.
Phenylephrine hydrochloride is a symphatomimetic directly affecting the adrenergic receptors. It has mainly alpha-adrenergic activity without affecting the central nervous system at usual doses.
Owing to irregular absorption and first-pass metabolism by monoamine oxidase in the gut and liver, Phenylephrine has low oral bioavailability.
Chlorpheniramine maleate, belongs to the class of alkylamine derivative. It is a sedating antihistamine that causes moderate degree of sedation. Chlorpheniramine also possesses antimuscarinic activity. It is commonly used for symptomatic relief of allergic conditions including rhinitis and conjunctivitis.
Following oral administration, Chlorpheniramine maleate is absorbed relatively slowly from the gastrointestinal tract. Peak plasma concentrations occur about 2.5 to 6 hours after oral doses.