Prolonged use of Cefaclor may result in overgrowth of non-susceptible organisms and as with other broad spectrum antibiotics, pseudomembranous colitis may develop. Cefaclor should not be given to patients who are hypersensitive to it or to other cephalosporins. About 10% of penicillin-sensitive patients may also be allergic to cephalosporins. Great care should be taken if Cefaclor is to be given to such patients. Care is also necessary in patients with known histories of allergy. Cefaclor should be given with caution to patients with renal impairment a dosage reduction may be necessary. Renal and haematological status should be monitored especially during prolonged and high-dose therapy.
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