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Each vial contains: Cefotaxime (as Sodium), USP 250 mg, 500 mg, or 1 g.
An off-white, pale yellowish powder 1.05 of monograph substance is approximately equivalent to 1 g of Cefotaxime. Freely soluble in water, particularly insoluble in organic solvents. Cefotaxime is a third generation cephalosporins antibiotic with an extended spectrum of activity and increased potency against Gram-negative bacteria including Enterobacteriaceae, Haemophilus influenza, Moraxella (Branhamella) catarrhalis, and Neisseria spp. But only moderate activity against Pseudomonas spp. Its active metabolite desacetylcefotaxime is given by injection as the sodium salt. Adverse effects are similar to those for all cephalosporins, including hypersensitivity reactions. There is some risk of colonization and superinfection with resistant organisms.
