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Increased nephrotoxicity with Probenecid, ethacrynic acid, furosemide, gentamicin and Vancomycin.
Disulfiram-like reaction with alcohol ingestion with cephalosporins with methyltetrazole-thiol (MT) side chain, eg. Cefamandole, cefoperazone, moxalactam and cefotetan.
High dose heparin, oral anticoagulants and other drugs that affect hemostasis. May increase the risk of hemorrhage with cephalosporins with MTT side chains.
