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Tablet: Levodopa: Citicoline may enhance the effects of levodopa. The exact mechanism is unknown, but animal models suggest that citicoline may increase dopamine levels in the brain and/or improve dopaminergic cell survival. In patients with Parkinson's disease, a few studies have demonstrated levodopa-saving effects, whereby the addition of citicoline (500 to 1200 mg/day) allowed for lower dosages of levodopa to be used with stable or improved therapeutic efficacy and reduced side effects in some patients. However, data are limited.
Coadministration with meclofenoxate: Citicoline must not be administered in conjunction with medication containing meclofenoxate (also known as Clophenoxate).
Injection: CITIFAR potentiates the effects of L-dopa and L-dihydroxy phenylalanine. It exhibits incompatibility and hence must not be administered in conjunction with medicaments containing meclofenoxate (also known as centrophenoxine).
