Citifar Overdosage

Tablet: Citicoline exhibits very low toxicity profile in humans. In a short term, placebo-controlled, cross-over study, 12 healthy adults took citicoline at daily doses of 600 and 1000 mg or placebo for consecutive five-day periods.
Transient headaches occurred in four subjects on 600-mg dose, five on the 1000-mg dose, and one in placebo.
No changes or abnormalities were observed in hematology, clinical biochemistry or neurological test.
The LD50 of a single intravenous dose of citicoline was 4,600 mg/kg and 4,150 mg/kg in mice and rats, respectively.
In an unpublished acute toxicity study, free-base citicoline was administered to male and female rats at a dose of 2000 mg/kg body weight for 14 days. No changes in body weight, deaths, clinical symptoms or gross pathological changes were observed.
Injection: CITIFAR exhibits very low toxicity profile in humans. Transient headache is reported most of the time after its overdosage. Therefore, it is not advisable to exceed the prescribed dosage of CITIFAR unless recommended by a healthcare provider. In case of accidental overdose, a symptomatic therapy should be carried out.