The incidence of adverse effects, particularly blood dyscrasias, is lower with Clopidogrel, although fatalities have been reported. Routine blood counts are not necessary, although they should be performed promptly when clinical signs suggest blood dyscrasias. Other adverse effects, reported rarely, include serum sickness, interstitial pneumonitis, erythema multiforme, Stevens-Johnson syndrome, lichen planus, and myalgia. Consideration should be given to stopping Clopidogrel 5 to 7 days before elective surgery.
Effects on taste: Loss of taste occurred in 2 patients 6 to 8 weeks after starting treatment with Clopidogrel, but recovered fully when Clopidogrel was withdrawn.
Hypersensitivity: Clopidogrel has been associated with hypersensitivity reactions including angioedema. There have also been reports of a hypersensitivity syndrome comprising fever, rash, and varying additional symptoms.