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Symptoms: The effects of overdosage are expected to be related primarily to salbutamol. Acute overdosage with ipratropium bromide is unlikely since ipratropium is not well absorbed systemically after administration.
Manifestation of overdosage with salbutamol include anginal pain, hypertension, hypokalemia and tachycardia. As with all sympathomimetic medications, cardiac arrest and even death may be associated with the abuse.
Treatment: Dialysis is not an appropriate treatment for overdosage of salbutamol as an inhalation aerosol; the judicious use of a cardiovascular β-receptor blocker eg, metoprolol tartrate may be indicated.
