Hypersensitivity to the active substance or to any of its excipients; acute venous or arterial thrombosis; Fibrinolytic conditions following consumption coagulopathy except in those with predominant activation of the fibrinolytic system with acute severe bleeding. Severe renal impairment (risk of accumulation); History of convulsions; Intrathecal and intraventricular injection, intracerebral application (risk of cerebral edema and convulsions).
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