Standard treatment of general fibrinolysis: 1 g (1 ampule of 10 ml or 2 ampules of 5 ml) tranexamic acid by slow intravenous injection (1 mL/minute) every 6 to 8 hours, equivalent to 15 mg/kg body weight.
Renal impairment: In renal insufficiency leading to a risk of accumulation, the use of tranexamic acid is contraindicated in patient with severe renal impairment. For patient with mild to moderate renal impairment, the dosage of tranexamic acid should be reduced according to the serum creatinine level: See Table 1.
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
Hepatic impairment: No dose adjustment is required for patients with hepatic impairment.
Pediatric Population: In children from 1 year, for current approved indications, the dosage is in the region of 20 mg/kg/day. However, data on efficacy, posology and safety for these indications are limited.
The efficacy, posology and safety of tranexamic acid in children undergoing cardiac surgery have not been fully established.
Elderly: No reduction in dosage necessary unless there is evidence of renal failure.
Method of Administration: The administration is strictly limited to slow intravenous injection.