Dalamax Drug Interactions

Clindamycin, which exhibits neuromuscular blocking activity, should not be used with drugs that have similar property (i.e. tubocurarine, pancuronium and atracurium). Concomitant use of the said drugs increases the risk of respiratory depression.
There were reports that clindamycin may inhibit the activity of aminoglycosides, in vitro. However, in vivo, there was neither antagonism observed nor any apparent decrease in the activity of clindamycin when given with aminoglycoside.
Diphenoxylate, loperamide and other opiate antidiarrheal drugs may exacerbate the symptoms of antibiotic-associated colitis by delaying the excretion of the toxin.
When kaolin-pectin suspension was given to patients taking clindamycin, the suspension did not affect the extent of absorption of clindamycin but it reduced its absorption rate significantly.
Concomitant use of clindamycin with parasympathomimetics such as neostigmine and pyridostigmine antagonizes the activity of the parasympathomimetics.