Deslogen Mechanism of Action

Pharmacology: Desloratadine a peripheral derivative related to azatadine, is a long-acting, non-sedating antihistamine with no significant antimuscarinic activity.
Pharmacodynamics: Desloratadine is a non-sedating, long-acting histamine antagonist with selective peripheral H1-receptor antagonist activity. After oral administration, desloratadine selectively blocks peripheral histamine H1-receptors because the substance is excluded from entry to the central nervous system.
Pharmacokinetics: Desloratadine is rapidly absorbed from the gastrointestinal tract after oral administration, peak plasma concentration is attained in about one hour. Bioavailability is increased and time of peak plasma concentrations is delayed when administered with food. Desloratadine undergoes extensive metabolism. The major metabolite, descarboethoxyloratadine has potent antihistamine activity. Reported mean elimination half-lives for desloratadine and descarboethoxyloratadine are 8.4 and 28 hours respectively. Desloratadine is about 98% bound to plasma proteins; descarboethoxyloratadine is less extensively bound. Desloratadine and its metabolites have been detected in breast milk, but do not appear to cross the blood-brain barrier to a significant extent. Most of a dose is excreted equally in the urine and faeces, mainly in the form of metabolites.