Loading dose: 750-1,500 mcg as single dose or in divided doses at 6-hrly intervals during initial 24-hr period if rapid digitalisation is required. Maintenance dose: 125-250 mcg daily or may range from 62.5-500 mcg daily. Patient w/ mild heart failure Loading dose may not be necessary & digitalisation may be achieved w/ 250 mcg once or bid.
View Digox overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypertrophic obstructive cardiomyopathy unless there is severe cardiac failure. Wolff-Parkinson-White syndrome or other evidence of accessory pathway especially if accompanied by atrial fibrillation.
Increased risk of toxicity w/ drugs that cause electrolyte disturbances. Thiazides & loop diuretics may cause hypokalemia & hypomagnesemia that may lead to cardiac arrhythmia. May cause hypokalemia w/ corticosteroids, β2 agonists (eg, salbutamol), amphotericin B, Na polystyrene sulfonate, carbenoxolone, & dialysis. Serum conc may be increased by quinidine, amiodarone & propafenone. Other antiarrhythmics may have additive effects on the myocardium increasing the likelihood of adverse effects. β-blockers may potentiate bradycardia. Increased conc w/ Ca channel blockers. Interactions may occur w/ drugs that affect P-gp action.
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