Digox Adverse Reactions

Digoxin and other glycosides commonly produce adverse effects because the margin between the therapeutic and toxic doses is small; plasma concentrations of Digoxin in excess of 2 nanograms / mL are considered to be an indication that the patient is at special risk although there is considerable interindividual variation. There have been many fatalities, particularly due to cardiac toxicity.
Nausea, vomiting and anorexia may be among the earliest symptoms of Digoxin toxicity or overdosage; diarrhea and abdominal pain may occur. Certain neurological effects are also common symptoms of Digoxin overdosage and include headache, facial pain, fatigue, weakness, dizziness, drowsiness, disorientation, mental confusion, bad dreams and more rarely delirium, acute psychoses, and hallucinations.
Visual disturbances including blurred vision may occur; color vision may be affected with objects appearing yellow or, less frequently, green, red, brown, blue or white. Hypersensitivity reactions are rare; thrombocytopenia has been reported. The cardiac glycosides may have some estrogenic activity and occasionally cause gynecomastia at therapeutic doses. The most serious side effects are those on the heart. Toxic doses may cause or aggravate heart failure.