Doxar Adverse Reactions

Losartan is generally well-tolerated. Adverse effects are usually mild and transient. Dizziness was the most common adverse effect reported. Other reported effects are headache, fatigue, neutropenia, asthenia, upper respiratory tract infection, back pain, gastrointestinal disturbances, fatigue, neutropenia and dose-related orthostatic hypotension. Hypotension was seen in patients particularly in those with volume depletion (i.e. patients on high dose diuretics).
Losartan may cause hyperkalemia in patients with chronic renal failure and in those receiving potassium-sparing diuretics or potassium supplements. Serum potassium and renal function must be monitored.
Rhabdomyolysis, anaphylactic reactions, angioedema with swelling of the larynx and glottis causing airway obstruction and/or swelling of the face, lips, pharynx and/or tongue have been reported rarely in patients treated with losartan. The drug appears less likely to cause cough and angioneurotic edema than ACE inhibitors.
Losartan has a uricosuric effect after single or multiple doses in salt-depleted or salt-loaded normotensive patients, sodium-depleted patients with essential hypertension, and hypertensive patients with intrinsic renal disease.