Doxar Contraindications

Losartan is contraindicated in patients who are hypersensitive to any component of the product.
Symptomatic hypotension may occur after losartan intake in patients who have intravascular volume depletion. This condition should be corrected prior to administration of losartan, or a lower staring dose should be used.
As a result of losartan's effect on the renin-angiotensin system, increased blood urea and serum creatinine have been reported in patients with bilateral renal artery stenosis in a solitary kidney, and renal failure in susceptible individuals.
Electrolyte imbalances are common in patients with renal impairment, and should be corrected. Serum potassium levels should be monitored in type II diabetic patients with proteinuria. Therapy with losartan in patients with hyponatremia, renal insufficiency volume depletion or in those treated aggressively with diuretics should be initiated at a reduced dosage as these patients are at greater risk of hypertension or deterioration of renal function.
A lower dose should be considered for patients with history of hepatic impairment, because of data demonstrating increased losartan levels in patients with cirrhosis.