Adult 400 mg once daily preferably as single dose in the evening. In certain cases, 400 mg bid is recommended on the basis of the clinical response. Doses as high as 1,200 mg daily (400 mg tid) may also be given.
Patients w/ HTN; heart, liver & renal disease; hypoxemia, hyperthyroidism, chronic right ventricular failure, CHF (prolonged plasma levels following discontinuation), history of peptic ulcer; COPD or concomitant infections; taking certain other drugs (eg, erythromycin, troleandomycin, lincomycin & other antibiotics of the same group, allopurinol, cimetidine, propranolol & anti-flu vaccine). Elderly.
Do not administer w/ other xanthine derivatives. Toxic synergism w/ ephedrine. Hepatic clearance may be decreased by erythromycin, troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol & anti-flu vaccine.
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