Doxofylline should not be administered together with other xanthine derivatives. Toxic synergism with ephedrine has been documented for xanthine. Like other xanthenes, concomitant therapy with erythromycin, troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propanolol and anti-flu vaccine may decrease the hepatic clearance of xanthenes, causing an increase in blood vessels. No evidence of a relationship between Doxofylline serum concentration and toxic events have been reported.
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