The frequent adverse effects observed are due to its contractile effect on smooth muscle, which are transient and reversible on cessation of therapy. These include vomiting, diarrhea, hyperpyrexia and flushing. The incidences of these common side effects during high dose treatment of Carboprost Tromethamine (Endoprost) can be minimized by pretreatment or co-administration of antiemetic and antidiarrheal drugs.