Epilepsy Adult & adolescent 900-3,600 mg/day.
Initially 300 mg on the 1st day of treatment, 300 mg bid on the 2nd day & 300 mg tid on the 3rd day. Thereafter, may increase dose in increments of 300 mg every 2-3 days until effective antiepileptic control is achieved which
is usually w/ in the range of 0.9-3.6 g daily. Max: 4.8 g daily in 3 equally divided doses. Max time interval between doses: 12 hr.
Peripheral neuropathic pain Adult 300 mg once daily in day, 300 mg bid in day 2 & 300 mg tid in day 3.
Alternatively, 900 mg/day as 3 equally divided doses.
Patient w/ renal impairment: CrCl ≥80 mL/min 900-3,600 mg/day in 3 divided doses,
50-79 mL/min 600-1,800 mg daily in 3 divided doses,
30-49 mL/min 300-900 mg daily in 3 divided doses,
15-29 mL/min 300 mg on alternate days to 600 mg daily in 3 divided doses,
<15 mL/min 300 mg on alternate days to 300 mg daily in 3 divided doses.
Patient undergoing hemodialysis Loading dose: 300-400 mg, followed by 200-300 mg after each 4-hr hemodialysis.
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