There is no known specific antidote for apalutamide overdose. No dose-limiting toxicities were observed at 480 mg daily (double the recommended daily dose).
It is advisable to contact a poison control center to obtain the latest recommendations for the management of an overdose.
Treatment:
In the event of an overdose, stop Apalutamide (Erleada), undertake general supportive measures until clinical toxicity has been diminished or resolved.