Allergy and hypersensitivity to Propacetamol, Paracetamol, Diethylglycine or similar compounds. Suspected allergy to propacetamol in any person handling propacetamol in any person handling propacetamol, especially healthcare personnel, and having presented with contact eczema. Severe liver disease. Concomitant anticoagulant treatment (risk of hematoma as with all drugs injectable by intramuscular route). As a general rule, this drug should not be used during the first trimester months of pregnancy.