Finarid Mechanism of Action

Pharmacology: Pharmacodynamics: Mechanism of Action: It is specific inhibitor of 5α-reductase, an intracellular enzyme that converts testosterone into the highly potent 5α-dihydrotestosterone which appears to be the principal androgen responsible for stimulation of prostate growth.
Onset of Action: Effects may be seen after a few months.
Duration of Action: Terminal elimination half life 4.8-6 hours.
Pharmacokinetics: Finasteride is adsorbed following oral administration and peak plasma concentrations are achieved in 1 to 2 hours. The mean bioavailability has variously been reported as 63% and 80%. It is about 90% bound to plasma protein. Finasteride is metabolized in the liver and excreted in urine and faeces as metabolites. The mean terminal half-life is about 6 hours in patients under 60 years of age but may be prolonged to about 8 hours in those 70 years of age or older.