Hepaclex Dosage/Direction for Use

In the prophylaxis of venous thromboembolism during surgical procedures, enoxaparin sodium is given by subcutaneous injection; treatment is continued for 7 to 10 days or until the patient is ambulant. Patients at low to moderate risk are given 20 mg (2000 units) once daily with the first dose approximately 2 hours pre-operatively. In patients at high risk, the dose should be increased to 40 mg (4000 units) once daily with the initial dose given approximately 12 hours before the procedure. Alternatively, a dose of 30 mg (3000 units) may be given subcutaneously twice daily, starting within 12 to 24 hours after operation. Following hip replacement surgery, enoxaparin may be continued in a dose of 40 mg once daily for a further 3 weeks. For the prophylaxis of thromboembolism in immobilized medical patients, the dose is 40 mg (4000 units) once daily for at least 6 days; treatment should be continued until the patient is fully ambulant, up to a maximum of 14 days.
For the treatment of deep-vein thrombosis enoxaparin sodium is given subcutaneously in a dose of 1 mg (100 units) per kg body-weight every 12 hours, or 1.5 mg (150 units) per kg once daily, for 5 days or until oral anticoagulation is established.
For prevention of clotting in the extracorporeal circulation during haemodialysis, enoxaparin sodium 1 mg (100 units) per kg is introduced into the arterial line of the circuit at the beginning of the dialysis session. A further dose of 0.5 to 1 mg (50 to 100 units) per kg may be given if required. The dose should be reduced in patients at high risk of hemorrhage. In the management of unstable angina, enoxaparin sodium is given subcutaneously in a dose of 1 mg (100 units) per kg every 12 hours. Treatment is usually continued for 2 to 8 days and low-dose aspirin should be given concomitantly.
Administration in infants and children: Increasing number of infants and children are receiving anticoagulants for the management of thromboembolism. Enoxaparin has been used for the treatment and prophylaxis of thromboembolism in children. A regimen of treatment of thromboembolism is 1.5 mg per kg body-weight every 12 hours for those under 2 months of age and 1 mg per kg every 12 hours for those over 2 months. Doses for prophylaxis are 0.75 mg per kg every 12 hours for those under 2 months and 0.5 mg per kg every 12 hours for those over 2 months.