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Hypersensitivity to metformin HCl or to any of the excipients of Humamet.
Patients with the following conditions: Renal disease or dysfunction, chronic liver disease, cardiac failure, recent myocardial infarction; acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma. Diabetic ketoacidosis should be treated with insulin. History of, or states associated with lactic acidosis or hypoxemia, alcoholism.
The use of Humamet should be stopped 2-3 days before surgery or clinical investigations eg, IV urography and IV angiography. It should be resumed only after control of renal function has been regained.
