Symptoms and signs: There are limited data on the effects of Ibrutinib (Imbruvica) overdose. No Maximum Tolerated Dose was reached in the phase 1 study in which patients received up to 12.5 mg/kg/day (1,400 mg/day). In a separate study, one healthy subject who received a dose of 1680 mg experienced reversible grade 4 hepatic enzyme increases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)]. There is no specific antidote for Ibrutinib (Imbruvica). Patients who ingested more than the recommended dose should be closely monitored and given appropriate supportive treatment.
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