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Pharmacology: Mefenamic Acid (ISTAN) belongs to a family of aspirin-like drugs that are derivatives of N-phenylanthranilic acid. It has analgesic as well as anti-inflammatory and antipyretic activities. As an analgesic, it displays both central and peripheral actions.
Pharmacokinetics: Absorption and Fate: Mefenamic Acid (ISTAN) is absorbed from the gastro-intestinal tract. Peak plasma concentrations occur about 2-4 hours after ingestion. The half life is reported to be 2-4 hours. Mefenamic Acid is extensively bound to plasma proteins. Over 50% of a dose may be recovered in the urine, as unchanged drug or conjugated metabolites.
Pregnancy and Neonate: Mefenamic acid given to nursing mothers was found in the breast milk in very small quantities.
