Kastair Drug Interactions

Montelukast may be administered with other drugs routinely used in the prophylaxis and chronic treatment of asthma and in the treatment of allergic rhinitis.
No clinically important effects were observed when montelukast was concomitantly administered with: benzodiazepines, decongestants, digoxin, nonsteroidal anti-inflammatory agents, oral contraceptives (ethinyl estradiol with norethindrone), prednisone, prednisolone, sedative hypnotics, terfenadine, theophylline, thyroid hormones, and warfarin.
Montelukast-treated patients with known aspirin sensitivity should continue to avoid aspirin and other NSAIDs. Although montelukast can improve airway function in asthmatics with aspirin sensitivity, the drug has not been shown to shorten the bronchoconstrictor response to aspirin or other NSAIDs in such patients.
The area under the plasma concentration-time curve of montelukast is decreased by approximately 40% with coadministration of phenobarbital. No dosage adjustment for montelukast is recommended. However, appropriate clinical monitoring should be initiated with concomitant administration of montelukast with potent cytochrome P450 enzyme inducers such as phenobarbital, phenytoin, and rifampicin.