View Lesofat overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food: Take immediately before, during or w/in 1 hr after each main meal. If a meal is missed or contains no fat, the dose may be omitted.
Contraindications
Hypersensitivity to orlistat. Chronic malabsorption syndrome. Cholestasis. Lactation.
Discontinue if patient does not lose at least 5% of their body-wt during the 1st 12 wk of therapy. Long-term therapy should not continue beyond 2 yr. Wt loss may affect the dosing of medicines for other conditions (eg, high cholesterol or diabetes). Over-consumption of fat & cal may reduce wt loss effect. May increase GI effects if taken w/ a very high fat meal; daily intake of fat should be distributed evenly over 3 main meals. Renal stones in patients suffering from CKD. Use of additional contraceptive method to prevent possible failure of OCs in case of severe diarrhea. Not recommended during pregnancy & lactation. Not intended for childn.
May modify the activity of anticoagulants (eg, warfarin), ciclosporin, iodine salts &/or levothyroxine, amiodarone, medicines for HIV. Reduced absorption of supplements of fat-soluble nutrients, particularly β-carotene & vit E. Decreased absorption of antiepileptic medicines. Acarbose.
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