Lesofat Drug Interactions

Other medicines and Orlistat: Tell the doctor or pharmacist if the patient is taking, has recently taken or might taken any other medicines.
This is important as taking more than one medicine at the same time can strengthen or weaken the effects of the medicines.
Orlistat may modify the activity of: Anticoagulant (medicine used as blood thinners, e.g, warfarin). The doctor may need to monitor the patient's blood coagulation.
Ciclosporin (medicine used to prevent organ rejection in transplant). Co-administration with ciclosporin is not recommended. The doctor may need to monitor the ciclosporin blood levels more frequently than usual.
Iodine salts and/or levothyroxine (medicines used to treat thyroid gland problems). Cases of hypothyroidism (condition when thyroid gland does not produce enough hormones) and/or reduced control of hypothyroidism may occur.
Amiodarone (medicine used for irregular heart beat). The patient may ask the doctor for advice.
Medicines to treat HIV.
Orlistat reduces the absorption of supplements of some fat soluble nutrients, particularly beta-carotene and vitamin E. The patient should therefore follow the doctor's advice in taking a well balanced diet rich in fruit and vegetables. The doctor may suggest the patient to take a multivitamins supplement.
Orlistat may unbalance an anticonvulsant (antiepileptic) treatment, by decreasing the absorption of antiepileptic medicines, thus leading to convulsions. Please contact the doctor if the patient thinks that the frequency and/or severity of the convulsions(seizure) have changed when taking Orlistat together with antiepileptic medicines.
Orlistat is not recommended for people taking acarbose (an anti-diabetic medicine used to treat type 2 diabetes mellitus).
Orlistat with food and drink: Orlistat can be taken immediately before, during a meal or up to one hour after a meal.