Levixa Dosage/Direction for Use

The usual dose of levofloxacin tablets is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection. It may be taken on an empty stomach or with meals. The dosage should be determined according to the sensitivity of the causative organism and the severity of the infection. For patients with normal renal function (creatinine clearance >50 mL/min), the following daily dosages are recommended: Acute bacterial exacerbations of chronic bronchitis: 500 mg for 7 days.
Nosocomial Pneumonia: 750 mg for 7-14 days.
Community-acquired Pneumonia: 500 mg for 7-14 days.
Acute Bacterial Sinusitis: 500 mg for 10-14 days.
Uncomplicated Skin and Skin Structure Infections: 500 mg for 7-10 days.
Complicated Skin and Skin Structure Infections: 750 mg for 7-14 days.
Chronic Bacterial Prostatitis: 500 mg for 28 days.
Uncomplicated Urinary Tract Infections: 500 mg 3 days.
Complicated Urinary Tract Infections: 750 mg 5 days.
Acute Pyelonephritis: 750 mg 5 days.
Administration in Renal Impairment: Levofloxacin is administered with caution in the presence of renal insufficiency. Careful clinical observation and appropriate laboratory studies should be performed prior to and during therapy since elimination of levofloxacin may be reduced. In patients with impaired renal function (creatinine clearance <50 mL/min), adjustment of the dosage regimen is necessary to avoid the accumulation of levofloxacin due to decreased clearance.