Levixa Overdosage

Based on animal studies, the most important adverse reactions to expect following acute overdosage of Levofloxacin are central nervous system symptoms such as confusion, dizziness, impairment of consciousness and convulsive seizures. The treatment of an overdosage is symptomatic and multivitamin preparations with zinc may interfere with the gastrointestinal absorption of levofloxacin, resulting in systemic levels considerably lower than desired. So, these agents should be taken at least two hours before or two hours after oral levofloxacin tablet.
The concomitant administration of a non-steroidal anti-inflammatory drug with a fluoroquinolone, including levofloxacin may increase the risk of CNS stimulation and convulsive seizures.
Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with fluoroquinolones and an antidiabetic agent. Therefore, careful monitoring of blood glucose is recommended when these agents are co-administered.
Geriatric Use: There was no apparent difference in the frequency or severity of adverse reactions in elderly adults compared with younger adults. The pharmacokinetic properties of levofloxacin in elderly subjects are similar to those in younger subjects. Drug absorption appears to be unaffected by age. Dosage adjustment is necessary for elderly patients with impaired renal function.