Lifezar Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Losartan K

Indications/Uses

Essential HTN in adults, childn & adolescents 6-18 yr. Renal disease in adult patients w/ HTN & type 2 DM w/ proteinuria ≥0.5 g/day as part of antihypertensive treatment. CHF in adult patients to whom ACE inhibitor is not suitable due to incompatibility, cough & contraindication. Reduction in risk of stroke in hypertensive adults w/ left ventricular hypertrophy documented by ECG.

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Dosage/Direction for Use

HTN & hypertensive type II diabetes w/ proteinuria ≥0.5 g/day Usual starting & maintenance dose: 50 mg once daily. Max: Antihypertensive effect is attained 3-6 wk after therapy initiation. May be increased to 100 mg once daily. Heart failure Initially 12.5 mg once daily titrated at wkly intervals as tolerated by patient. Max: 150 mg once daily. Reduction in the risk of stroke in hypertensive patient w/ left ventricular hypertrophy documented by ECG Initially 50 mg once daily. Add low dose hydrochlorothiazide &/or increase Lifezar dose to 100 mg daily based on BP response. Patient w/ intravascular vol depletion 25 mg once daily. Childn 6-18 yr >20-50 kg Initially 25 mg once daily. Adjust dose according to BP response. Max: 50 mg once daily, >50 kg 50 mg once daily. Max: 100 mg once daily.

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Overdosage

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Administration

May be taken with or without food: Swallow w/ glass of water.

Contraindications

Hypersensitivity. Concomitant use w/ aliskiren in type 2 diabetes patients. Severe hepatic impairment. Pregnancy.

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Special Precautions

Hypersensitivity. History of angioedema. Patients who are vol- & Na-depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea or vomiting. Monitor plasma conc of K & CrCl; renal function. Concomitant use w/ K-sparing diuretics, K supplements & K-containing salt substitutes; ACE inhibitors; β-blocker. Severe hepatic impairment. Bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Avoid in severe renal impairment (GFR <30 mL/min). Kidney transplantation. Primary hyperaldosteronism. CHD & cerebrovascular disease. Heart failure. Aortic & mitral valve stenosis, obstructive hypertrophic cardiomyopathy. Dual blockade of the renin-angiotensin system. May affect ability to drive & use machines. Pregnancy & lactation. Black people. Childn w/ hepatic impairment, GFR <30 mL/min/1.73 m².

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Use In Pregnancy & Lactation

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Adverse Reactions

Dizziness; vertigo; hyperkalaemia, hypoglycaemia, increased blood urea, serum creatinine & serum K; asthenia, fatigue; anaemia; orthostatic hypotension (including dose-related orthostatic effects); renal impairment & failure.

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Drug Interactions

Increased incidence of hypotension, hyperkalaemia & changes in renal function w/ angiotensin receptor blocker. May have increased hypotensive action w/ other antihypertensives. May increase risk of hypotension w/ hypotension-inducing products (eg, TCAs, antipsychotics, baclofene & amifostine). Decreased exposure w/ CYP2C9 inhibitor eg, fluconazole. Reduced plasma conc w/ rifampicine. May increase serum K w/ drugs which retain K (eg, K-sparing diuretics, amiloride, triamterene, spironolactone, K supplements or salt substitutes containing K) or K levels w/ heparin. May reversibly increase serum lithium conc & toxicity. May attenuate antihypertensive effect w/ NSAIDs (ie, selective COX-2 inhibitors, ASA & non-selective NSAIDs). May increase risk of renal function worsening w/ diuretics & NSAIDs.

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Caution For Usage

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Storage

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Description

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Action

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MIMS Class

Angiotensin II Antagonists

ATC Classification

C09CA01 - losartan ; Belongs to the class of angiotensin II receptor blockers (ARBs). Used in the treatment of cardiovascular disease.

Regulatory Classification

Presentation/Packing

Form

Lifezar FC tab 100 mg

Packing/Price

30's (P1,511.63/pack)

Form

Lifezar FC tab 50 mg

Packing/Price

30's (P1,295.08/pack)

Lifezar

losartan

Manufacturer:

Therapharma

Distributor:

United Lab