Hypersensitivity to the active substance or to any of the excipients (see Precautions); pregnancy (see Use in Pregnancy & Lactation); severe hepatic impairment; concomitant use of angiotensin receptor antagonists (ARBs)-including losartan-or of angiotensin-converting-enzyme inhibitors (ACEIs) with aliskiren in patients with Type 2 diabetes (see Dual blockade of the Renin-Angiotensin-System (RAS) with ACEIs, ARBs or aliskiren under Interactions).