Pharmacology:Pharmacokinetics: Metformin Hydrochloride is slowly and incompletely absorbed from the gastrointestinal tract; the absolute bioavailability of a single 500-mg dose is reported to be about 50 to 60%, although this is reduced somewhat if taken with food. Following absorption, plasma protein binding is negligible, and it is excreted unchanged in the urine. The plasma elimination half-life is reported to range from about 2 to 6 hours after oral administration.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign Out
