Selective serotonin reuptake inhibitors are less sedating than tricyclic antidepressants (TCAs) and have fewer antimuscarinic and cardiotoxic effects. Adverse effects reported with SSRIs include dry mouth and gastrointestinal disturbances eg, nausea, vomiting, dyspepsia, constipation and diarrhea. Anorexia and weight loss may also occur. Neurological adverse effects have included either anxiety, restlessness, nervousness, insomnia or drowsiness and fatigue; headache, tremor, dizziness, seizures, hallucinations, confusion, agitation, extrapyramidal effects, depersonalization, mania, panic attacks, sexual dysfunction and symptoms suggestive of a serotonin syndrome have occurred. Excessive sweating, pruritus, skin rashes, alopecia, photosensitivity and urticaria have been reported. Angioedema and anaphylactoid reactions have occurred.
Excessive sweating, pruritus, skin rashes, alopecia, photosensitivity and urticaria have been reported. Angioedema and anaphylactoid reactions have occurred.