In general, mupirocin is well-tolerated after topical application. Most adverse effects of mupirocin are mild and transient. The following local adverse effects have been reported rarely in patients using Mupicin ointment: Application site reactions, burning, stinging, pain, pruritus, rash, dryness, erythema, tenderness, cellulitis, pain or bleeding secondary to eczema, secondary wound infection, urticaria, swelling, contact dermatitis, furunculosis, exfoliative dermatitis, increased exudates, and cutaneous sensitization reactions to mupirocin or to the ointment base.
The following systemic effects have occurred very rarely in patients receiving topical mupirocin: Systemic allergic reactions, nausea, headache, dizziness, abdominal pain, and ulcerative stomatitis.