Mupicin Special Precautions

For external use on the skin only.
Avoid contact with the eyes. If the ointment comes in contact with the eyes, rinse out promptly and thoroughly with water.
Do not use at the site of central venous cannulation.
As with other polyethylene glycol-based ointments, do not use mupirocin ointment in conditions where large amount of polyethylene glycol may be absorbed (e.g., in open wounds, extensive burns, broken skin), particularly in patients with moderate or severe renal impairment.
In cases of sensitivity or severe local irritation, discontinue mupirocin treatment and consult a physician.
As with other antibacterial products, long term use may result in overgrowth of non-susceptible organisms, including fungi.
Carcinogenesis, Mutagenesis & Impairment of Fertility: The carcinogenic potential of mupirocin has not been evaluated in long-term animal studies.
The mutagenic potential of mupirocin has been investigated in vitro and in vivo using rat primary hepatocyte unscheduled DNA synthesis, sediment analysis for DNA strand breaks, the Ames test, Escherichia coli mutation assay, metaphase analysis of human lymphocytes, mouse lymphoma assay and bone marrow micronuclei assay in mice. Results of these studies did not indicate a potential for genotoxicity.
Studies in male and female rats have shown that subcutaneous doses up to 14 times the human topical dose (about 60 mg/day) on a mg/m² basis was found to have no evidence of impairment on fertility and reproductive performance attributable to mupirocin.
Use in Pregnancy: (Pregnancy Category B.) Animal studies have demonstrated no evidence of impaired fertility or harmful effects to the fetus. There are no adequate and well-controlled studies in pregnant women. Since animal studies are not always predictive of human response, use this drug during pregnancy only if clearly needed.
Use in Lactation: It is not known whether mupirocin is excreted in human milk. Since many drugs are distributed into human milk, use with caution when breastfeeding. If a cracked nipple is to be treated with mupirocin, lactation from the affected breast should be maintained by manual expression until the end of treatment. During this time, milk from the affected breast should be discarded.
Use in Children: The safety and efficacy of Mupicin ointment have not been established in children 2 months to 16 years.
Use in Elderly: The safety and efficacy of mupirocin in elderly patients more than 65 years are comparable to those in younger adults.