Nefrotein Drug Interactions

The simultaneous administration of medicaments containing calcium (e.g. acetolyte) may lead to pathological increases of the serum calcium level or intensification.
As the uraemic symptoms improve under Ketoanalogues + Essential amino acids (Nefrotein), a possible administration of aluminum hydroxide should be reduced. Pay attention to a reduction of serum phosphate. In order not to interfere with absorption, do not take drugs together with Ketoanalogues + Essential amino acids (Nefrotein) that form sparingly soluble compounds with calcium (e.g. tetracyclines, quinolone e.g. ciprofloxacin and norfloxacin, iron-, fluoride- and estramustin-containing drugs). Between the intake of Ketoanalogues + Essential amino acids (Nefrotein) and drugs from the mentioned categories, a period of at least 2 hours should pass. The susceptibility towards heart/cardiac-active glycosides and hence also the risk of arrhythmia increases with the rise of blood calcium concentration.