Administer by continuous IV infusion only. Dilute to conc of 0.1-0.2 mg/mL before use unless given by central venous line.
Adult Initially at rate of 3-5 mg/hr for 15 min continuous administration. Rates can be increased by increments of 0.5 or 1 mg every 15 min. Infusion rate should not exceed 15 mg/hr. Maintenance dose: Reduce dose progressively, usually to between 2 & 4 mg/hr, when target pressure is reached to maintain therapeutic efficacy.
Childn Initially 0.5-5 mcg/kg/min in case of emergency. Maintenance dose: 1-4 mcg/kg/min.
Elderly, hepatic & renal impairment, pregnancy Initially 1-5 mg/hr continuous infusion, depending on BP & clinical situation. Increase or decrease rate by increments of 0.5 mg/hr after 30 min depending on effect observed. Rate should not exceed 15 mg/hr.
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