Discontinue use if neuroleptic malignant syndrome occurs. Patients w/ impaired liver & kidney, known history of CV disease (eg, heart failure, MI, conduction abnormalities, dehydration, hypovolemia or cerebrovascular disease), hyperprolactinemia, Parkinson's disease, unstable epilepsy, wt gain. Dose reduction should be considered if hypotension occurs. May affect ability to drive or operate machinery. Pregnancy & lactation. Childn <15 yr.
Akathisia, anxiety, nervousness, impaired vision, sexual disorders, decreased extrapyramidal effects, polyuria, change in mental status.
Drug Interactions
Amplified effects of depression w/ alcohol. May increase the effect of orthostatic hypotension in patients taking antihypertensives. Eliminated effects of bromocriptine or pergolide therapy. Antagonize the effect of levodopa & dopamine agonists. Decreased clearance w/ clozapine. Increased clearance w/ carbamazepine.
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