Absorption of vitamin B12 from the GI tract may be decreased by aminoglycoside antibiotics, colchicine, extended-release potassium preparations and aminosalicylic add and its salts, anticonvulsants (e.g. phenytoin, phenobarbital, primidone), cobalt irradiation of the small bowel, and by excessive alcohol intake lasting longer than 2 weeks. Neomycin-induced malabsorption of vitamin B12 may be increased by concurrent administration of colchicine.
Alpha lipoic acid may improve blood sugar control, so people with diabetes who are taking medication to lower blood sugar, such as metformin, glyburide, should only take alpha lipoic acid under supervision of a qualified health professional and have their blood sugar levels carefully monitored.
Medication that slow blood cloning (Anticoagulant/Antiplatelet drugs) interacts with Inositol Nicotinate.