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Each uncoated tablet contains: Betahistine hydrochloride BP 16 mg. Excipients: q.s.
Betahistine hydrochloride is a white to almost white crystalline powder, which is very hygroscopic. The product is very soluble in water, freely soluble in methanol and 96% ethanol, and slightly soluble in isopropanol. The pKa values are 3.5 and 9.7. Betahistine hydrochloride is an antivertigo drug. It is commonly prescribed patients with balance disorders or to alleviate vertigo symptoms associated with Meniere's disease. The drug increases histamine endogenous production and also functions as a weak histamine receptor H1 agonist and H3 receptor antagonist. Betahistine chemically is 2-[2-(methylamino)ethyl]pyridine, and is formulated as the dihydrochloride salt. Its structure closely resembles that of phenethylamine and histamine.
