Ome-M Mechanism of Action

Pharmacology: Pharmacokinetics: Distribution: The apparent volume of distribution in healthy subjects is approximately 0.3 L/kg body weight. Omeprazole is 97% plasma protein bound.
Elimination: Total plasma clearance is about 30-40 L/h after a single dose. The plasma elimination half-life of Omeprazole is usually shorter than one hour both after single and repeated once-daily dosing. Omeprazole is completely eliminated from plasma between doses with no tendency for accumulation during once-daily administration. Almost 80% of a dose of Omeprazole is excreted as metabolites in the urine, the remainder in the faeces, primarily originating from bile secretion.
Special populations: Hepatic impairment: The metabolism of Omeprazole in patients with liver dysfunction is impaired, resulting in an increased AUC. Omeprazole has not shown any tendency to accumulate with once-daily dosing.
Renal impairment: The pharmacokinetics of Omeprazole, including systemic bioavailability and elimination rate, are unchanged in patients with reduced renal function.
Older people: The metabolism rate of Omeprazole is somewhat reduced in elderly subjects (75-79 years of age).