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Two cases of omeprazole overdose were characterized by drowsiness, headache (possibly due to a metabolite) and tachycardia. Both patients recovered without specific treatment.
Intravenous doses of 270 mg given in a day and up to 650 mg over a three-day period in clinical trials did not show any dose-related adverse reactions. As in all cases where overdosing is suspected, treatment should be symptomatic and supportive.
