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Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use of Amoxicillin with Clavulanic acid may result in increased and prolonged blood levels of Amoxicillin.
Amoxicillin with clavulanic acid may reduce the efficacy of oral contraceptives.
The possibilities of prolonged bleeding time in individuals receiving anticoagulants concurrently should be borne in mind.
Penicillins may reduce the excretion of methotrexate causing a potential increase in toxicity.
