Paizu Caution For Usage

Special precautions for disposal and other handling: The reconstitution and dilution is to be made under aseptic conditions. The solution is to be inspected visually for particulate matter and discoloration prior to administration. The solution should only be used if the solution is clear and free from particles.
Intravenous use: Reconstitute each vial with the volume of solvent shown in the table below, using one of the compatible solvents for reconstitution. Swirl until dissolved. When swirled constantly, reconstitution generally occurs within 3 minutes (for details on handling, please see as follows). (See Table 7.)

Click on icon to see table/diagram/image

The reconstituted solutions should be withdrawn from the vial by syringe. When reconstituted as directed, the vial contents withdrawn by syringe will provide the labelled amount of piperacillin and tazobactam.
The reconstituted solutions may be further diluted to the desired volume (e.g. 50 mL to 150 mL) with one of the following compatible solvents: sodium chloride 9 mg/mL (0.9%) solution in water for injection; glucose 50 mg/mL (5%) solution in water for injection;
dextran (grade 40) 60 mg/mL (6%) solution in sodium chloride 9 mg/mL (0.9%) solution.
Any unused medicinal product or waste material should be disposed in accordance with local requirements.
For single use only. Discard any unused solution.
This medicinal product must not be mixed with other medicinal products except those mentioned in Special precautions for disposal and other handling.
This product must not be mixed or co-administered with any aminoglycoside. The mixing of beta-lactam antibiotics with an aminoglycoside in vitro can result in substantial inactivation of the aminoglycoside.
Piperacillin/tazobactam should not be mixed with other substances in a syringe or infusion bottle since compatibility has not been established.
Piperacillin/tazobactam should be administered through an infusion set separately from any other medicinal products unless compatibility is proven.
Due to chemical instability, piperacillin/tazobactam should not be used in solutions containing only sodium bicarbonate.
Lactated Ringer's (Hartmann's) solution is not compatible with piperacillin/ tazobactam. Piperacillin/tazobactam should not be added to blood products or albumin hydrolysates.