Referis Mechanism of Action

Therapeutic Category: Iron supplement.
Pharmacology: Pharmacodynamics: Following intravenous administration of Iron sucrose is dissociated by the reticuloendothelial system into iron and sucrose.
Pharmacokinetics: In healthy adults treated with intravenous doses of Iron sucrose (Referis) injection, its iron component exhibits first order kinetics with an elimination half-life of 6h, total clearance of 1.2 L/h, non-steady state apparent volume of distribution of 10.0 L and steady state apparent volume of distribution of 7.9 L. Since iron disappearance from serum depends on the need for iron in the iron stores and iron utilising tissues of the body, serum clearance of iron is expected to be more rapid in iron deficient patients treated with Iron sucrose injection as compared to healthy individuals. The effects of age and gender on the pharmacokinetics of Iron sucrose injection have not been studied.
Distribution: Following intravenous administration of iron sucrose, the iron component appears to distribute mainly in blood and to some extent in extravascular fluid. Significant amount of the administered iron distributes in the liver, spleen and bone marrow.
Metabolism and Elimination: Following intravenous administration of Iron sucrose (Referis) is dissociated into iron and sucrose by the reticuloendothelial system. The sucrose component is eliminated mainly by urinary excretion. Some iron also is eliminated in the urine.